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Title: [Can water be poisonous?]. Author: Artunc F, Schnauder G, Gallwitz B, Amend B. Journal: Dtsch Med Wochenschr; 2015 Nov; 140(23):1761. PubMed ID: 26583822. Abstract: HISTORY AND ADMISSION FINDINGS: Two female patients aged over 80 years developed central nervous symptoms after drinking large amounts of water (more than 3 l per day). INVESTIGATIONS: Both had a hypoosmolar hyponatremia that was induced by concomitant treatment with hydrochlorothiazid (HCT) in the one case and in the other case relied on a distal tubular damage due to reflux nephropathy. DIAGNOSIS, TREATMENT AND COURSE: Hyponatremia was corrected after withdrawal of HCT and fluid restriction and central nervous symptoms disappeared rapidly. CONCLUSIONS: Distal tubular urinary dilution can be disturbed by HCT and parenchymal renal disease and can result in symptomatic hyponatremia after drinking large amounts of water.[Abstract] [Full Text] [Related] [New Search]