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  • Title: [Analgosedation with midazolam and fentanyl as an alternative to general anesthesia in transvaginal follicle puncture within the scope of in vitro fertilization].
    Author: Bein T, Klapproth CE.
    Journal: Anasth Intensivther Notfallmed; 1989 Apr; 24(2):77-80. PubMed ID: 2658673.
    Abstract:
    The technique of in vitro fertilization (IVF) was simplified by the development of ultrasound-supported transvaginal follicular centesis. This makes it possible to dispense with general anesthesia. As an alternative, an intravenous analgosedation with midazolam (0.1 mg/kg) and fentanyl (2 micrograms/kg) is presented. Besides a good analgesic and anxiolytic action, an incipient respiratory depression was observed, so that insufflation of oxygen-enriched air is to be recommended. The operation is felt to be comfortable by almost all patients. A high degree of anterograde amnesia is attained. Meticulous intraoperative and postoperative anesthesiological monitoring is a prerequisite for application of this procedure.
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