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  • Title: Characterization of Urinary Stone Composition by Use of Third-Generation Dual-Source Dual-Energy CT With Increased Spectral Separation.
    Author: Duan X, Li Z, Yu L, Leng S, Halaweish AF, Fletcher JG, McCollough CH.
    Journal: AJR Am J Roentgenol; 2015 Dec; 205(6):1203-7. PubMed ID: 26587926.
    Abstract:
    OBJECTIVE: The purpose of this phantom study was to determine the utility of a third-generation dual-source CT scanner with increased dual-energy spectral separation in differentiating urinary stone composition. MATERIALS AND METHODS: Eighty-seven urinary stones from humans were scanned in 35-, 40-, 45-, and 50-cm wide anthropomorphic phantoms with a third-generation dual-source scanner (system A) with a high-energy beam of 150 kV plus 0.6-mm tin filtration (Sn). The low-energy data were acquired at 70, 80, 90, and 100 kV. A second-generation dual-source scanner (system B) was used to acquire data at 140 kV plus 0.4-mm Sn for the high-energy and 80 or 100 kV for the low-energy images. Volume CT dose index was matched for a given phantom size. CT number ratios were calculated and used to differentiate uric acid from non-uric acid stones and oxalate from apatite stones in an ROC analysis. RESULTS: The area under the curve (AUC) of the ROC curve for uric acid versus non-uric acid stones increased for large phantoms. For example, for imaging of the 45-cm wide phantom with system A at the 100- and 150-kV Sn low- and high-energy combination, the AUC was 0.99, whereas for system B at the 100- and 140-kV Sn combination, the AUC was 0.86. At each phantom size and for all energy combinations, the AUC values for oxalate versus apatite stones were higher for system A than they were for any energy combination for system B. CONCLUSION: Compared with use of second-generation dual-source CT, use of third-generation dual-source CT at the energy combination of 100 and 150 kV Sn improved classification of urinary stones across a wide range of phantom sizes and increased the ability to differentiate oxalate from apatite stones.
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