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  • Title: [THE ROLE OF HEME-CONTAINING GLOBINS IN HYPOXIC NO-SIGNALING OF VERTEBRATE CELLS].
    Author: Kuleva NV, Krasovskaya IE.
    Journal: Tsitologiia; 2015; 57(8):563-71. PubMed ID: 26591567.
    Abstract:
    Nitric oxide is one of the most important signaling molecule of living organisms. It may be produced by two ways: from arginine by means of NO-syntases and from nitrite by means of nitrite reductases. The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities. Hypoxic NO-signaling depends on oxygen concentration and is important for exercise, vascular hypoxic vasodilation, myocardial preconditioning and angiogenesis. Data of scientific literature of last 15 years show that the nitrite-reductase activity of heme-containing globins was used for oxygen sensing and ROS/RNS defence at early stages of life evolution.
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