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  • Title: Glucose-induced insulin secretion from perifused isolated islets in rats.
    Author: Imamura S.
    Journal: Nihon Ika Daigaku Zasshi; 1989 Feb; 56(1):72-8. PubMed ID: 2659620.
    Abstract:
    Glucose-induced insulin secretion in rat pancreas islets was studied by means of the modified perifusion technique. The biphasic insulin increase after 0.3% glucose application consisted of a rapid response (the first phase response) and a delayed one (the second phase response). The former was brought about by shortening the 0.3% glucose application time to one and a half minutes and the latter by treatment with 1 microgram/ml of synthetic somatostatin. It was proposed that the rapid response depended mainly on D-cell activity and the delayed response depended on B-cell function.
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