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  • Title: [Treatment of Parkinson tremor by chronic stimulation of the ventral intermediate nucleus of the thalamus].
    Author: Benabid AL, Pollak P, Hommel M, Gaio JM, de Rougemont J, Perret J.
    Journal: Rev Neurol (Paris); 1989; 145(4):320-3. PubMed ID: 2660224.
    Abstract:
    Stereotactic ventral intermediate nucleus (Vim) thalamotomy may improve drug resistant severe parkinsonian tremor. However, tremor may recur and bilateral thalamotomy is known to induce unacceptable side effects in a proportion of patients. A high frequency (130 Hz) chronic Vim stimulation was performed in 4 parkinsonian patients, 2 of them having previously undergone a thalamotomy on the other side. Tremor was suppressed in all patients at the price of slight paresthesias. This improvement has been lasting from 2 to 14 months. Beneficial and adverse effects were suppressed at once each time the stimulation was stopped. These preliminary results are encouraging but a longer delay and more patients are obviously needed.
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