These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prolonged minor allograft survival in intravenously primed mice. Effect of recipient's age and of prior immunity to minor H antigens on the priming cells.
    Author: Johnson LL.
    Journal: Transplantation; 1989 Jun; 47(6):1017-20. PubMed ID: 2660339.
    Abstract:
    The effect of a pretransplant i.v. infusion of donor-strain spleen cells into recipient mice that were already immune to minor H antigens on the infused cells was studied. The central finding is that a preexisting state of immunity against target minor H antigens on a skin graft is sufficient to overcome the survival-prolonging effect of a pretransplant i.v. infusion of donor-strain spleen cells. Moreover, immunity directed against an irrelevant antigen on the infused cells, rather than against a target antigen on the indicator skin graft, is sufficient to cause the beneficial effect of the infusion to be greatly reduced. A further significant finding is that the ability of a pretransplant infusion of donor-strain spleen cells to prolong the survival of a minor allograft of skin declines as the recipient matures from a 6-9-week-old juvenile to a 12-16-week-old adult.
    [Abstract] [Full Text] [Related] [New Search]