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  • Title: [The effect of blood serum components on the growth, biochemical and biological properties of streptococcus].
    Author: Savel'ev EP, Bitko SA, Dynga LO, Shmakova ZF, Smirnova MN.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1989 Apr; (4):6-10. PubMed ID: 2660478.
    Abstract:
    The components of cattle blood serum, added to the medium for the cultivation of group A streptococci, considerably decrease the period of adaptation and increase the balanced growth rate of streptococci, which is manifested by changes in the surface structures of the cell wall: the absence or modification of protein M. Streptococci grown under these conditions lose their capacity for phagocytosis, and from the cell walls obtained from these streptococci no surface protein M can be isolated by pepsin treatment. Nevertheless, the ratio of the main cell-wall components (proteins, polysaccharide and peptidoglycan), the amino acid composition, as well as the resistance of the cell walls to the action of trypsin and endo-N-acetylmuramidase are the same in M+ and Mx variants, that makes it possible to infer that the modification of protein M or the inhibition of its synthesis occurs during the growth of streptococci in the presence of blood serum components.
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