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  • Title: [Current aspects of bacterial resistance to antibiotics].
    Author: Brisson-Noel A, Trieu-Cuot P, Sougakoff W, Courvalin P.
    Journal: Ann Biol Clin (Paris); 1989; 47(2):98-101. PubMed ID: 2660637.
    Abstract:
    New aspects of the evolution of bacterial antibiotic resistance are discussed. Dissemination of antibiotic resistance appears to be unlimited since resistance genes from Gram-positive cocci have been detected in Gram negative bacteria. This suggests the occurrence of heterogramic genetic transfers between these phylogenetically distinct organisms. New characters of resistance to beta-lactam antibiotics in enterobacteria result from the apparition of mutant of the TEM-1 and TEM-2 penicillinases. Mutations that confer the capacity to hydrolyze the third generation cephalosporins are located in the active site of the enzymes.
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