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  • Title: Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53.
    Author: Moon SH, Jung Y, Kim SH, Kim I.
    Journal: Bioorg Med Chem Lett; 2016 Jan 01; 26(1):110-3. PubMed ID: 26608553.
    Abstract:
    Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.
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