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  • Title: [Prenatal diagnosis and prognosis of oligo-anhydramnia].
    Author: Voigt HJ, Grünsteidel W, Faschingbauer C.
    Journal: Geburtshilfe Frauenheilkd; 1989 Apr; 49(4):350-6. PubMed ID: 2661305.
    Abstract:
    From 1986 to 1987, a total of 56 cases with oligoanhydramnia as indicative symptom were examined and treated in the Prenatal Unit of the Gynaecological Department of the University of Erlangen. In cases of difficult fetal imaging, new antenatal diagnostic methods, like artificial instillation of amniotic fluid, transabdominal chorionic villus sampling and blood flow measurement by Doppler sonography were used. With the exception of three cases of primary placental disturbances, an accurate prenatal diagnosis was established in 95%. As expected, development disorders of the fetal urinary tract were in 45% of all cases most frequent. In 39% a malformation could be ruled out. Chromosomal aberrations appeared in 7%. Doppler sonography was helpful in differentiating the cases of fetal growth retardation caused by a disturbed placental circulation, from those cases emanating from congenital fetal anomalies. Compared to polyhydramnia, in which 70% of the cases are idiopathic, oligoanhydramnia as primary symptom is, in our opinion, of greater clinical significance. This is proved by a high rate of both malformations (60%) and mortality (68%). Considering the frequently delayed admission of such patients and, in most cases the poor outcome, increased attention to the symptom of oligoanhydramnia, during sonographic screening examinations, is necessary. Early admission to a prenatal diagnostic unit for clarification by differentiated methods permits the establishment of the presence or absence of a disease picture incompatible with a healthy life status.
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