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  • Title: Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
    Author: Nishio M, Tomatsu K, Konishi M, Tomita K, Oki T, Kawaguchi H, Clardy J.
    Journal: J Antibiot (Tokyo); 1989 Jun; 42(6):852-68. PubMed ID: 2661511.
    Abstract:
    A complex of new antifungal antibiotics designated karnamicin was isolated from the cultured broth of Saccharothrix aerocolonigenes No. N806-4. Fifteen components have so far been isolated from the complex; the major component karnamicin B2 was identified by X-ray crystallography to be a novel molecule unrelated to known antibiotics. All components of karnamicin exhibited a rather broad spectrum of activity against fungi and yeasts with MICs ranging from 3.1 to 50 micrograms/ml.
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