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  • Title: ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata with their inhibitory activities on LPS-induced NO production in RAW 264.7 macrophages.
    Author: Liu ZG, Li ZL, Li DH, Li N, Bai J, Zhao F, Meng DL, Hua HM.
    Journal: Bioorg Med Chem Lett; 2016 Jan 01; 26(1):1-5. PubMed ID: 26615888.
    Abstract:
    Ten ent-abietane diterpenoids (1-10), including four new (1-4) and six known ones (5-10) were isolated from the roots of Euphorbia ebracteolata. Their structures were determined by 1D, 2D NMR, and HRESIMS. Compounds 2, 4, and 7 exhibited significant inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 0.69, 1.97, and 0.88μM, respectively. A primary structure-activity relationship was also discussed.
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