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  • Title: In vitro biosynthesis of beta-endorphin in pituitary glands.
    Author: Crine P, Benjannet S, Seidah NG, Lis M, Chrétien M.
    Journal: Proc Natl Acad Sci U S A; 1977 Apr; 74(4):1403-6. PubMed ID: 266182.
    Abstract:
    beta-Endorphin is a 31 amino acid polypeptide isolated from the pituitary gland of different species of animals. It has strong morphine-like activity. It is formed of amino acid residues 61-91 of beta-lipotropin. Speculation has arisen whether it is biosynthesized in situ or transformed after secretion of beta-lipotropin. The present in vitro studies show that it is found as beta-endorphin in bovine pituitary slices incubated with radioactive amino acid precursor [35S]methionine. Chemical characterization and microsequencing of the newly biosynthesized material proves its identity with isolated unlabeled beta-endorphin and shows that it has a methionine residue at its fifth position, as expected.
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