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  • Title: Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine.
    Author: Chen Z, Zhou S, Jia Y.
    Journal: J Org Chem; 2015 Dec 18; 80(24):12545-51. PubMed ID: 26619294.
    Abstract:
    The formal synthesis of (+)-kopsihainanine A has been achieved via stereoselective reduction of tetracyclic iminium ion intermediates (24). However, attempts to synthesize (+)-limaspermidine by reduction of the same tetracyclic iminium ion intermediates have failed. The synthesis features a Suzuki cross-coupling reaction, a cyclization reaction mediated by trifluoromethanesulfonic anhydride, and stereoselective reduction of an iminium ion.
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