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  • Title: Briarenolides U-Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae).
    Author: Su YD, Wu TY, Wen ZH, Su CC, Chen YH, Chang YC, Wu YC, Sheu JH, Sung PJ.
    Journal: Mar Drugs; 2015 Dec 03; 13(12):7138-49. PubMed ID: 26633428.
    Abstract:
    Five new 13,14-epoxybriarane diterpenoids, briarenolides U-Y (1-5), were isolated from the octocoral Briareum sp. The structures of briaranes 1-5 were elucidated by spectroscopic methods. Briarenolides U-Y (1-5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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