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  • Title: Elevated placenta growth factor levels in the early second-trimester amniotic fluid are associated with preterm delivery.
    Author: Lee H, Kwon JY, Lee S, Kim SJ, Shin JC, Park IY.
    Journal: J Matern Fetal Neonatal Med; 2016 Oct; 29(20):3374-8. PubMed ID: 26634962.
    Abstract:
    OBJECTIVE: The purpose of this study was to determine how angiogenesis-related factors correlate with preterm delivery. METHODS: A cohort of 382 pregnant women undergoing early second-trimester genetic amniocentesis was enrolled and followed-up until delivery, and the amniotic fluid was collected and stored as a nested case-control study. Cases with preterm delivery (n = 31) were compared with matched controls with term delivery (n = 62). The amniotic fluid concentrations of placenta growth factor (PlGF), angiogenins, angiopoietin-2, soluble fms-like tyrosine kinase and soluble endoglin were determined using enzyme-linked immunosorbent assays. RESULTS: Women who delivered preterm had a higher amniotic PlGF concentration compared with the control group (median 12.6 pg/ml versus 6.1 pg/ml; p=0.027). Other angiogenesis-related factors did not show any differences between case and control groups. The odds ratio for preterm delivery based on amniotic fluid PlGF was 1.031 (95% confidence interval: 1.002-1.061; p=0.035). Additionally, when the cases were subdivided into early preterm, late preterm and term groups, PlGF values between the early preterm and term delivery groups were significantly different (median 16.6 pg/ml versus 6.1 pg/ml; Bonferroni-adjusted p=0.018). CONCLUSION: Amniotic fluid PlGF levels in the early second trimester of pregnancy are associated with preterm delivery.
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