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  • Title: An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: enantioselective Ni(ii)-catalyzed Michael addition of 2-acetyl azaarene to β,β-disubstituted nitroalkenes.
    Author: Hou X, Ma H, Zhang Z, Xie L, Qin Z, Fu B.
    Journal: Chem Commun (Camb); 2016 Jan 25; 52(7):1470-3. PubMed ID: 26649776.
    Abstract:
    The first example of a highly enantioselective Michael addition of 2-acetyl azaarenes with β,β-disubstituted nitroalkenes was achieved using a Ni(acac)2-bisoxazoline complex as a catalyst, which afforded chiral compounds with an all-carbon quaternary stereocenter bearing a CF3 group in good yields with excellent enantioselectivities (up to >99% ee). This reaction, featuring mild conditions, excellent enantioselectivity and broad generality, provides a new efficient strategy for the construction of trifluoromethylated all-carbon quaternary stereocenters.
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