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  • Title: G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb.
    Author: Gewirtz AM, Anfossi G, Venturelli D, Valpreda S, Sims R, Calabretta B.
    Journal: Science; 1989 Jul 14; 245(4914):180-3. PubMed ID: 2665077.
    Abstract:
    Exposure of peripheral blood mononuclear cells (PBMC) to an 18-base c-myb antisense oligomer before mitogen or antigen stimulation resulted in almost complete inhibition of c-myb messenger RNA and protein synthesis and blockade of T lymphocyte proliferation. Expression of early and late activation markers, interleukin-2 receptor and transferrin receptor, respectively, by PBMC was unaffected by antisense oligomer exposure as was the expression of c-myc messenger RNA. In contrast, histone H3 messenger RNA levels and DNA content were selectively decreased. These results suggest that c-myb protein deprivation does not perturb T lymphocyte activation or early molecular events that may prepare the cell for subsequent proliferation. Rather, it appears to specifically block cells in late G1 or early S phase of the cell cycle.
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