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  • Title: Time-dependent inactivation of glucose-6-phosphate dehydrogenase from yeast by aluminum.
    Author: Cho SW, Joshi JG.
    Journal: Toxicol Lett; 1989 Jun; 47(3):215-9. PubMed ID: 2665187.
    Abstract:
    Aluminum inhibited yeast glucose-6-phosphate dehydrogenase (EC 1.1.1.49) by a pseudo-first-order reaction. The inhibition was proportional to the incubation time and the concentration of aluminum. Double reciprocal plots gave a straight line with a kinact of 8.3 min-1 and indicated the presence of a binding step prior to inhibition. The kinetic study showed that 1 mol of aluminum was bound per mol of enzyme subunit.
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