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  • Title: Effect of norharman on the mutagenicity of toluidine metabolites.
    Author: Gupta RL, Kaur IP, Gupta AK, Pathak DP, Juneja TR.
    Journal: Toxicol Lett; 1989 Jul; 48(1):75-81. PubMed ID: 2665189.
    Abstract:
    Among the different metabolites of o-toluidine only the nitroso and hydroxylamino derivatives were found to be very potent frameshift mutagens in the presence of the co-mutagen norharman and S9. In the absence of norharman and S9 they are only base pair mutagens. Norharman failed to evoke the mutagenicity of the non-carcinogenic m- and p-toluidine and their respective nitroso and hydroxylamino metabolites. This report highlights that norharman plays a role in the appearance of mutagenicity of certain carcinogenic amines and metabolites.
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