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  • Title: Bioanalytical method validation for the simultaneous determination of ceftazidime and avibactam in rat plasma.
    Author: Beaudoin ME, Gangl ET.
    Journal: Bioanalysis; 2016; 8(2):111-22. PubMed ID: 26652586.
    Abstract:
    BACKGROUND: Combination therapies have gained momentum in the disease management strategies of various indications. While it is challenging and more time consuming to develop a combined analytical method, the strategy of simultaneous analysis offers significant advantages in terms of efficiency and cost-effectiveness. RESULTS: Due to a significant difference in efficacious dose for ceftazidime and avibactam, the calibration ranges validated in this paper were set to 0.05-50 μg/ml for ceftazidime and 0.005-5.0 μg/ml for avibactam. Interday results of ceftazidime were within 8% for accuracy and 9% for precision and within 9% for both accuracy and precision of avibactam. CONCLUSION: A sensitive and selective LC-MS/MS method was developed for the simultaneous quantification of ceftazidime and avibactam in rat plasma.
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