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  • Title: Buccal administration of human colostrum: impact on the oral microbiota of premature infants.
    Author: Sohn K, Kalanetra KM, Mills DA, Underwood MA.
    Journal: J Perinatol; 2016 Feb; 36(2):106-11. PubMed ID: 26658119.
    Abstract:
    OBJECTIVE: To determine whether the administration of mother's colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants. STUDY DESIGN: In this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for 46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing. RESULT: The oral microbiota changed markedly over the 96 h period in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the dominant families at 48 and 96 h, respectively, in the control group. CONCLUSION: Buccal administration of mother's colostrum to VLBW infants influenced the colonization of the oral cavity with differences persisting 48 h after completion of the intervention.
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