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  • Title: Molecular and cellular regulation of neuropeptide expression: the bag cell model system.
    Author: Arch S, Berry RW.
    Journal: Brain Res Brain Res Rev; 1989; 14(2):181-201. PubMed ID: 2665891.
    Abstract:
    The bag cell neuroendocrine system of Aplysia californica has been under intensive investigation for nearly two decades. The favorable morphology and hardiness in organ culture of this preparation have permitted a wide range of electrophysiological, cellular, and molecular studies. In this review we have focused our attention on the biochemical and physiological processes that serve the principle function of the bag cells: the synthesis and secretion of the neuropeptide egg-laying hormone. Although these cells were at first considered a model system for the most elementary neuroendocrine mechanisms, increasing knowledge has disclosed a surprising degree of complexity in both neuropeptide biosynthesis and the electrophysiological processes responsible for secretion. Not only may various components of the prohormone be sorted into different classes of neurosecretory granules, which may in turn have different probabilities of secretion, but biosynthesis itself appears to be regulated by the same intracellular messengers that mediate the electrophysiological discharge cycle. Hence, the bag cells, and presumably other peptidergic neurons, appear to possess an array of regulatory processes that can modulate the amount and character of their secretory output. The interactions of these processes may confer a degree of plasticity to the functional expression of peptidergic neurons unanticipated in studies of other neuron types.
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