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  • Title: Does the Capsule Interfere with Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Cryptococcus neoformans and Cryptococcus gattii?
    Author: Thomaz DY, Grenfell RC, Vidal MS, Giudice MC, Del Negro GM, Juliano L, Benard G, de Almeida Júnior JN.
    Journal: J Clin Microbiol; 2016 Feb; 54(2):474-7. PubMed ID: 26659203.
    Abstract:
    We described the impact of the capsule size for Cryptococcus neoformans and Cryptococcus gattii identification at the species level by Bruker matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). After experimental capsule size modulation, we observed that reducing the capsule size resulted in improved identification by Bruker MALDI-TOF MS across all of the reference strains analyzed.
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