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  • Title: [Behavioral phenotypes of autism spectrum disorder patients and their parents].
    Author: Situ M, Hu X, Cai J, Guo K, Huang Y.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2015 Dec; 32(6):797-800. PubMed ID: 26663051.
    Abstract:
    OBJECTIVE: To explore the relationship between the behavior phenotypes of patients with autism spectrum disorder (ASD) and their parents through family study. METHODS: Forty-five core families with ASD and 30 control families from Chengdu area were examined using Autism Spectrum Quotient (AQ). Descriptive statistical analysis, correlation analysis, and Logistic regression analysis were used to investigate the effect of various factors, especially genetic factors that may affect the pathogenesis of ASD. RESULTS: The social skills factor and communication factor of the father's AQ scale, as well as the mother's age of childbearing and AQ social skills factor are related to whether children with ASD (R were 0.46, 0.39, 0.39 and 0.36, P<0.05). The communication factor of the parents' AQ and mother's attention to detail factor are related to whether children will show developmental anomaly before the age of 36 months (R were 0.55, 0.51 and 0.54, P<0.05). The social skill problems of parents and father's communication problems are risk factors for children with autism. CONCLUSION: ASD may be influenced by both genetic and environmental factors. The autistic behavior phenotype of parents is a risk factor for ASD and is associated with developmental anomalies of early childhood.
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