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  • Title: Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Natural Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum.
    Author: Clark TN, Ellsworth KT, Jean S, Webster D, Robichaud GA, Johnson JA, Gray CA.
    Journal: Nat Prod Commun; 2015 Oct; 10(10):1647-8. PubMed ID: 26669094.
    Abstract:
    An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A (1) and 6(E)-phomopsolide A (2). This is the first report of antimycobacterial activity for 1 and 2.
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