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  • Title: Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp.
    Author: Lv F, Daletos G, Lin W, Proksch P.
    Journal: Nat Prod Commun; 2015 Oct; 10(10):1667-70. PubMed ID: 26669100.
    Abstract:
    Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.
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