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  • Title: Synthesis and oral hypoglycemic properties of two 4-oxo-4,5,6,7-tetrahydroindole-3-acetic acids.
    Author: Nagarajan K, Talwalker PK, Goud AN, Shah RK, Shenoy SJ.
    Journal: Arzneimittelforschung; 1989 May; 39(5):548-50. PubMed ID: 2667524.
    Abstract:
    Condensation of beta-acetyl-2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexene-1-propionic acid (3) with n-butyl and isobutylamines affords the title acids 4 and 5, respectively, which show good oral hypoglycemic activity in normal rats. Acids 4 and 5, are also active in streptozocin-induced diabetic rats. Results of extensive pharmacological and acute toxicity tests are reported.
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