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  • Title: On the regulatory properties of the pyruvate kinase from Trypanosoma cruzi epimastigotes.
    Author: Cazzulo JJ, Cazzulo Franke MC, Franke de Cazzulo BM.
    Journal: FEMS Microbiol Lett; 1989 Jun; 50(3):259-63. PubMed ID: 2668108.
    Abstract:
    The pyruvate kinase from Trypanosoma cruzi epimastigotes was activated by fructose 2,6-diphosphate ((A) 0.5 = 0.17 microM), through a decrease in (S) 0.5 and an increase in Vmax for both substrates. The enzyme was 50% inhibited by 0.9 mM ATP or 0.5 mM Pi in the presence of 30 mM MgCl2; these inhibitions were completely counteracted by 1.5 microM fructose 2,6-diphosphate. Both facts suggest that the effects are allosteric, and not due to chelation.
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