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  • Title: Exposure to volatile anaesthetics is not followed by a massive induction of single-strand DNA breaks in operation theatre personnel.
    Author: Szyfter K, Stachecki I, Kostrzewska-Poczekaj M, Szaumkessel M, Szyfter-Harris J, Sobczyński P.
    Journal: J Appl Genet; 2016 Aug; 57(3):343-8. PubMed ID: 26685861.
    Abstract:
    Volatile anaesthetics such as halothane, isoflurane and others were expected to produce a health challenge for operation room personnel because of prolonged occupational exposure to anaesthetic gases. To estimate a molecular background of adverse health effects, a cohort of 100 exposed individuals was studied by the single-cell gene electrophoresis (comet assay) test. DNA lesions in lymphocytes of the exposed group did not differ significantly compared with non-exposed blood donors. Then, the exposed group was further divided according to job position. A highest level of DNA lesions was established in nurses but without significant difference compared with other groups. When a time period of exposure was taken into account, a tendency to cumulate DNA lesions was found only in the group of anaesthesiologists. A very weak genotoxic effect established in this study is discussed in relation to DNA repair, adaptative response and potential self-elimination of sensitive individuals.
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