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  • Title: [Biosynthesis of oleandomycin by cultures of Streptomyces antibioticus obtained after regeneration and fusion of protoplasts].
    Author: Shevchenko AA, Matseliukh BP, Sobachkina IS, Tyshchenko AF, Orekhova VM.
    Journal: Mikrobiol Zh (1978); 1989; 51(2):22-5. PubMed ID: 2668708.
    Abstract:
    The ability of Streptomyces antibioticus strains to synthesize oleandomycin is studied under the effect of regeneration and fusion of protoplasts. The production of strains-regenerants with an increased (by 30-50%) synthesis of oleandomycin is possible. Regenerants of mutants resistant to the proper antibiotic retain a high level of the oleandomycin synthesis more stably. Variations in the antibiotic-production ability are considered in regenerant populations of various generations.
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