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  • Title: [Ala6]gastrin-releasing peptide-10: an analogue with dissociated biological activities.
    Author: Mukai H, Kawai K, Suzuki S, Ohmori H, Yamashita K, Munekata E.
    Journal: Am J Physiol; 1989 Aug; 257(2 Pt 1):E235-40. PubMed ID: 2669516.
    Abstract:
    COOH-terminal decapeptide of gastrin-releasing peptide (GRP-10) is a bombesin-like peptide, which has bioactivities to stimulate gastrin, insulin, and glucagon secretion. We have synthesized an analogue of GRP-10 that inhibits GRP-10's stimulation of insulin secretion both in vivo and in vitro and glucagon secretion in vivo, while potentiating the stimulation of gastrin secretion. The amino acid sequence of this peptide is H-Gly-Asn-Trp-Ala-Ala-Gly-His-Leu-Met-NH2 ([Ala6]GRP-10). Because the stimulation of insulin and gastrin secretion by GRP-10 has been ascribed to a direct effect on B- and G-cells, these findings suggest that there are two subtypes of receptors for bombesin-like peptides in mammalian tissues.
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