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Title: State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" - research activities and scientific advance in 2014.
Author: Bazyka D, Sushko V, Chumak A, Buzunov V, Talko V, Yanovich L.
Journal: Probl Radiac Med Radiobiol; 2015 Dec; 20():12-24. PubMed ID: 26695891.
Abstract:
Research activities and scientific advance achieved in 2014 at the State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine" (NRCRM) concerning medical problems of the Chornobyl disaster, radiation medicine, radiobiology, radiation hygiene and epidemiology in collaboration with the WHO network of medical preparedness and assistance in radiation accidents are outlined in the annual report.Epidemiological cohort studies found increased incidence (1990-2012 gg.) of thyroid cancer in victims of Chernobyl accident (liquidators - in 4.6 times, evacuated - in 4.0 times, residents of contaminated areas - in 1.3 times) and increased incidence of breast cancer in female workers of 1986-1987. (in the 1994-2012 biennium. SIR = 160,0%, 95% CI: 142,4-177,6). Retrospective studies of thyroid cancer ("case control") in cohorts and 152 thousand of liquidators were continued together with the US National Cancer Institute. Radiation risks of multiple myeloma and chronic lymphocytic leukemia were found.Molecular effects of remote period after radiation exposure include changes in gene expression TERF1, TERF2, CCND1, telomere length, the protein expression of cyclin D1, histone gamma H2AX. An association of molecular changes with cognitive deficits were defined. Genetic polymorphisms of rs2981582 gene FGFR2, rs12443621 gene TNRC9, rs3817198 gene LSP1, rs3803662 gene TNRC9, rs889312 gene MAP3K1 and their association with breast can cer were studied; the expression by tumor cells of estrogen and progesterone receptor, antigens of c kit, cytoker atins 5/6, TP53 and ki67, amplification status of the gene Her2 / neu, mutation status of the genes BRCA1 (muta tions 185delAG and 5382insC) and BRCA2 (mutation 6174delT) were studied. The possibility of persistence of radi ation modified hidden chromosomal instability in consecutive generations of human somatic cells was proven.The status of reproductive function and peculiarities of baby nutrition in population of contaminated areas were studied. In the framework of National social programs for improving safety, occupational health and working envi ronment in 2014 2018 for the first time in Ukraine developed and successfully completed intercalibration of 18 lab oratories for individual monitoring. Studying of medical effects of radiation in interventional cardiologists was started.Experimental studies concerned the impact of radiomodyficans on cell systems. The report also shows the results of scientific organizational and health care work, staff training.The NRCRM Annual Report was approved at the Scientific Council meeting of NAMS on March 17, 2015. Shchorichnyy zvit vidobrazhuie osnovni rezul'taty diial'nosti DerzhavnoI ustanovy „Natsional'nyy naukovyy tsentr radiatsiynoI medytsyny Natsional'noI akademiI medychnykh nauk UkraIny ” (NNTsRM) z medychnykh problem Chorno byl's'koI katastrofy, radiatsiynoI medytsyny, radiobiologiI, radiatsiynoI gigiieny ta epidemiologiI, spivpratsi z VOOZ v merezhi medychnoI gotovnosti ta dopomogy pry radiatsiynykh avariiakh u 2014 r.Epidemiologichnymy kogortnymy doslidzhenniamy vstanovleno zrostannia zakhvoriuvanosti (1990–2012 rr.) na rak shchytopodibnoI zalozy u postrazhdalykh vnaslidok avariI na ChAES (ULNA – u 4,6 raza, evakuyovanykh – u 4,0 ra zy, meshkantsiv zabrudnenykh terytoriy – u 1,3 raza) ta zrostannia chastoty raku molochnoI zalozy u zhinok ULNA 1986–1987 rr. (u 1994–2012 rr. SIR = 160,0%, 95% DI: 142,4–177,6). Spil'no z Natsional'nym instytutom raku CShA prodovzheno retrospektyvne doslidzhennia raku shchytopodibnoI zalozy „vypadok kontrol' ” v kogorti 152 tys. likvidatoriv. Vstanovleno radiatsiyni ryzyky miielomnoI khvoroby ta khronichnoI limfotsytarnoI leykemiI.Molekuliarni efekty viddalenogo periodu pislia oprominennia vkliuchaly zminy ekspresiI geniv TERF1, TERF2, CCND1, dovzhyny telomer, ekspresiI bilka cyclin D1, gistonu gamma H2AX. Vyznacheno asotsiatsiiu molekuliarnykh zmin z kognityvnym defitsytom. Vyvcheno genetychni polimorfizmy rs2981582 gena FGFR2, rs12443621 gena TNRC9, rs3817198 gena LSP1, rs3803662 gena TNRC9 i rs889312 gena MAP3K1 ta Ikh asotsiatsiiu z rakom molochnoI zalozy; ekspresiiu klitynamy pukhlyny retseptoriv estrogenu ta progesteronu, antygeniv c kit, tsytokeratynu 5/6, TP53 ta ki67, amplifikatsiynyy status gena Her2/neu, mutatsiynyy status geniv BRCA1 (mutatsiI 185delAG ta 5382insC) i BRCA2 (mutatsiia 6174delT). Dovedeno mozhlyvist' persystentsiI radiatsiyno modyfikovanoI prykhovanoI khromosom noI nestabil'nosti u poslidovnykh generatsiiakh somatychnykh klityn liudyny.U naselennia vyvcheno stan reproduktyvnoI funktsiI, osoblyvosti dytiachogo kharchuvannia na radioaktyvno zabrud nenykh terytoriiakh. V ramkakh vykonannia Zagal'noderzhavnoI sotsial'noI programy polipshennia stanu bezpeky, gigiieny pratsi ta vyrobnychogo seredovyshcha na 2014–2018 roky vpershe v UkraIni rozrobleno y uspishno vykonano interkalibruvannia dlia 18 laboratoriy indyvidual'nogo dozymetrychnogo kontroliu. Rozpochato doslidzhennia efektiv medychnogo oprominennia u interventsiynykh kardiologiv.Eksperymental'ni doslidzhennia stosuvalysia vplyvu radiomodyfikatoriv na klitynni systemy.V zviti takozh vidobrazheno rezul'taty naukovo organizatsiynoI, likuval'no profilaktychnoI roboty, pidgotovky kadriv ta vprovadzhennia.Zvit NNTsRM zatverdzheno na zasidanni NaukovoI rady NAMN UkraIny 17.03.2015 r.

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