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  • Title: Evaluation of median survival patients with acute lymphoblastic leukemia exposed to ionizing radiation by the Chornobyl accident, depending on the aminoacid composition of stromal fibroblasts bone marrow and indicators of myelogram.
    Author: Bebeshko VG, Bruslova KM, Tsvyetkova NM, Volodina TT, Pushkarova TI, Lyashenko LO, Panchenko LM, Iatsemirskii SM.
    Journal: Probl Radiac Med Radiobiol; 2015 Dec; 20():311-8. PubMed ID: 26695910.
    Abstract:
    OBJECTIVE: To investigate the aminoacid composition in the stromal fibroblasts of bone marrow and indexes of hemogram in children with acute lymphoblastic leukemias, which exposed to radiation from the Chornobyl accident, for evaluation of the median survival. MATERIALS AND METHODS: In the study 54 patients with acute lymphoblastic leukemia, residents of Kyiv, Zhytomyr and Chernihiv regions of Ukraine were involved. Effectiveness of stromal fibroblasts colony forming units of bone marrow and aminoacid composition of fibroblasts were studied. Bone marrow examination was conducted on day33 and after stop of chemotherapy, the median survival of patients and exposure dose were evaluated. RESULTS: In children with acute leukemias effectiveness of stromal fibroblasts of bone marrow was 2-2,3 times lower than normative. Correlation (rs = +0,83) between the number of erythroid progenitor cells in the bone marrow and proline content in stromal fibroblasts established . The correlation between patients median survival and number of granulocytes in myelogram (rs = + 0,82) was proven. Mean exposure doses in patients was (5,86 ± 1,11) mSv and it did not correlate with myelogram results, effectiveness of stromal fibroblasts of bone marrow and median survival. CONCLUSIONS: The median survival of patients with acute leukemias depends on the content of amino acids in stro mal fibroblasts of bone marrow and recover of hematopoiesis after chemotherapy. Meta. Vyvchennia aminokyslotnogo skladu stromal'nykh fibroblastiv kistkovogo mozku ta pokaznykiv gemogramy u ditey z gostrymy limfoblastnymy leykemiiamy, iaki zaznaly vplyvu ionizuiuchogo vyprominennia vnaslidok Chorno byl's'koI avariI, dlia otsinky mediany vyzhyvanosti.Materialy ta metody. Obstezheno 54 khvorykh na gostri limfoblastni leykemiI, zhyteliv KyIvs'koI, Zhytomyrs'koI ta Chernigivs'koI oblastey UkraIny. Vyvchaly efektyvnist' koloniieutvoriuiuchykh odynyts' fibroblastiv kistkovogo mozku ta aminokyslotnyy sklad fibroblastiv. Doslidzhennia kistkovogo mozku provodylys' na 33 y den' khimiote rapiI ta pislia zakinchennia likuvannia; otsiniuvaly medianu vyzhyvanosti khvorykh ta dozy oprominennia. Rezul'taty. U ditey z gostrymy leykemiiamy efektyvnist' stromal'nykh fibroblastiv kistkovogo mozku v 2–2,3 ra za nyzhcha, porivniano z normatyvnoiu. Vstanovleno koreliatsiynyy zv’iazok (rs = +0,83) mizh chyslom erytroIdnykh klityn poperednykiv u kistkovomu mozku ta vmistom prolinu v stromal'nykh fibroblastakh. Dovedeno koreliatsiynu zalezhnist' mizh medianoiu vyzhyvanosti khvorykh ta chyslom granulotsytiv v miielogrami (rs = +0,82). Dozy opromi nennia khvorykh skladaly (5,86 ± 1,11) mZv i ne koreliuvaly z pokaznykamy miielogramy, efektyvnistiu koloniieut vorennia stromal'nykh fibroblastiv ta medianoiu vyzhyvanosti.Vysnovky. Mediana vyzhyvanosti khvorykh na gostri leykemiI zalezhyt' vid vmistu aminokyslot u stromal'nykh fibroblastakh kistkovogo mozku ta protsesiv vidnovlennia kistkovomozkovogo krovotvorennia pislia provedennia khimioterapiI.
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