MEDLINE/PubMed Journal Browser Search

Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

Title: Optimization of chronic obstructive pulmonary disease treatment in clean-up workers of the Chornobyl NPP accident in the remote period after irradiation.
Author: Sushko VO, Shvaiko LI, Bazyka KD, Riazhska AS.
Journal: Probl Radiac Med Radiobiol; 2015 Dec; 20():457-66. PubMed ID: 26695922.
Abstract:
BACKGROUND: According to the results of the clinical and epidemiological studies in clean-up workers of Chernobyl NPP accident in the remote period were detected the growth of morbidity of chronic obstructive pulmonary disease with substantial features of pathomorphosis, that make difficulties for treatment. The aim of the study was to determine the effectiveness of long-term administration (6 months) combination Аmbroxol (30 mg x 3 times per day) and Essenciale (600 mg x 2 times per day) added to basic treatment in patients with moderate to severe COPD - clean-up workers of the Chornobyl NPP accident. MATERIALS AND METHODS: Studied 60 COPD patients before treatment and after 1 year from the beginning, who were randomly assigned to two groups: the first group of patients ( 32 persons ) additionally was appointed long reception (6 months) combination ambroxol (30 mg three times a day ) and Essenciale (600 mg twice daily ), in the second group (28 people) patients received only basic therapy. The doses of radiation exposure were 25 - 500 mSv. Were studied clinical, functional characteristics, the number of exacerbations. RESULTS AND CONCLUSIONS: Low response to the basic COPD therapy were shown by clean-up workers of the Chornobyl NPP accident, which is defined by the absence of significant changes in lung function tests. Additional appointments to the basic treatment of COPD ambroxol combination (30 mg 3 g / d) of Essenciale (600 mg 3 g / d) within 6 months of the liquidators of the Chernobyl possible to reduce the frequency of exacerbations in 46.9% patients without significant improvement in lung function tests. Aktual'nist'. Za rezul'tatamy klinichnykh i epidemiologichnykh doslidzhen' u uchasnykiv LNA na ChAES u viddalenomu periodi vyiavleno zrostannia zakhvoriuvanosti na khronichne obstruktyvne zakhvoriuvannia legeniv z istotnymy osoblyvostiamy patomorfozu, shcho pryzvodyt' do trudnoshchiv u likuvanni. Meta doslidzhennia vyznachyty efektyvnist' dovgotryvalogo pryiomu (6 misiatsiv) kombinatsii ambroksolu (30 mg kh 3 r/d) ta essentsiale (600 mg kh 2 r/d) na foni bazysnoi terapii v uchasnykiv LNA na ChAES, iaki khvoriiut' na KhOZL seredn'ogo ta tiazhkogo stupenia. Materialy ta metody doslidzhennia: Doslidzheno 60 khvorykh na KhOZL do pochatku likuvannia, ta cherez 1 rik vid pochatku, iakykh bulo randomizovano u dvi grupy: pershii grupi khvorykh (32 osoby) dodatkovo bulo pryznacheno dovgotryvalyi pryiom (6 misiatsiv) kombinatsii ambroksolu (30 mg trychi na den') ta essentsiale (600 mg dvichi na den'), u drugii grupi (28 osib) patsiienty otrymuvaly lyshe bazysnu terapiiu. Poglynuta doza oprominennia skladala 25 – 500 mZv. Vyvchalys' klinichni ta funktsional'ni pokaznyky, kil'kist' zagostren'. Rezul'taty ta vysnovky: V uchasnykiv LNA na ChAES efektyvnist' bazysnoi terapii KhOZL bula nyz'koiu, dostovirnogo pokrashchennia pokaznykiv spirografii ne vidmicheno. Dodatkove pryznachennia do bazysnoi terapii KhOZL kombinatsii ambroksolu (30 mg kh 3 r/d) z essentsiale (600 mg kh 3 r/d) vprodovzh 6 misiatsiv v uchasnykiv LNA na ChAES dozvolylo zmenshyty chastotu zagostren' u 46,9 % patsiientiv bez suttievogo pokrashchennia pokaznykiv ventyliatsiinoi funktsii legen'.

[Abstract] [Full Text] [Related] [New Search]