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  • Title: Label-free optical-resolution photoacoustic microscopy of superficial microvasculature using a compact visible laser diode excitation.
    Author: Zeng L, Piao Z, Huang S, Jia W, Chen Z.
    Journal: Opt Express; 2015 Nov 30; 23(24):31026-33. PubMed ID: 26698732.
    Abstract:
    We have developed laser-diode-based optical-resolution photoacoustic microscopy (LD-OR-PAM) of superficial microvasculature which has the desirable properties of being compact, low-cost, and label-free. A 300-mW visible pulsed laser diode was operated at a 405 ± 5 nm wavelength with a pulse energy as low as 52 nJ. By using a 3.6 MHz ultrasound transducer, the system was tested on carbon fibers with a lateral resolution of 0.95 µm and an SNR of 38 dB. The subcutaneous microvasculature on a mouse back was imaged without an exogenous contrast agent which demonstrates the potential of the proposed prototype for skin chromophores. Our eventual goal is to offer a practical and affordable multi-wavelength functional LD-OR-PAM instrument suitable for clinical applications.
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