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  • Title: Quantitative Investigation on Correlation Between IgG and FcRn During Gestation and Lactating Periods in Rat.
    Author: Wang Y, Jiang X, He J, Diraviyam T, Zhang X.
    Journal: Am J Reprod Immunol; 2016 Feb; 75(2):81-5. PubMed ID: 26699647.
    Abstract:
    PROBLEM: IgG is transformed from maternal serum into the offspring as passive immunization by FcRn expressed in placenta and/or infant intestine. This study aimed to investigate the quantitative correlation between IgG and FcRn during gestation and lactating periods in rat. METHOD OF STUDY: ELISA was performed to determine the variation of maternal and offspring IgG. Western blot and RT-qPCR were carried out to characterize FcRn expression in placenta and infant intestine. RESULTS: Maternal serum IgG appeared higher in first 2 weeks of lactation. The embryo IgG was in accordance with the FcRn expression in placenta. During the post-natal, the serum IgG concentration in feta was obviously lower than maternal IgG on day 0 before uptaking colostrums and rapidly increased on day 1. CONCLUSION: These findings would provide clues for the endogenous transportation and exogenous administration of IgG for a better IgG intervention in offspring.
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