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  • Title: Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos.
    Author: Gan JH, Hu WZ, Yu HB, Yang F, Cao MX, Shi HJ, Kang YF, Han BN.
    Journal: J Asian Nat Prod Res; 2015; 17(12):1231-8. PubMed ID: 26699877.
    Abstract:
    Three new aaptamine derivatives (1-3), together with six known related compounds (4-9), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated on the basis of spectroscopic analyses. Compounds 1, 4, 5, 7, and 9 showed cytotoxic activities against HeLa, K562, MCF-7, and U937 cell lines with IC50 values in the range of 0.90-12.32 μM.
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