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  • Title: [Halofantrine in the treatment of malaria. Clinical trial in a semi-rural zone of Cameroon].
    Author: Raccurt CP, Ribou G, Lambert MT, Bouloumie J, Macaigne F, Ripert C.
    Journal: Bull Soc Pathol Exot Filiales; 1989; 82(3):368-72. PubMed ID: 2670289.
    Abstract:
    Twelve children, 2 to 15 years of age, with falciparum malaria (parasitaemia 4,500 to 170,000/mm3) have taken 24 mg/kg body weight of halofantrine hydrochloride (Halfan) per os in three divided doses given within 12 hours. The symptomatology improved after 24 to 48 hours, with no more fever 5 to 90 hours after treatment and with a decrease of splenomegaly in 80% of the cases. The parasitic clearance was obtained after 24 to 60 hours. The haematocrit started raising again in 58% of the cases. Halofantrine hydrochloride is an efficient antimalarial drug in semi-immune patients. It is well tolerated and well accepted, thus representing an alternative for the cure of chloroquine-resistant falciparum malaria.
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