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  • Title: Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents.
    Author: Mokale SN, Palkar AD, Dube PN, Sakle NS, Miniyar PB.
    Journal: Bioorg Med Chem Lett; 2016 Jan 15; 26(2):272-276. PubMed ID: 26707395.
    Abstract:
    A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL).
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