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  • Title: A new coumarin from stem bark of Mesua hexapetala.
    Author: Karunakaran T, Ee GC, Teh SS, Daud S, Mah SH, Lim CK, Jong VY, Awang K.
    Journal: Nat Prod Res; 2016 Jul; 30(14):1591-7. PubMed ID: 26710827.
    Abstract:
    A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity.
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