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  • Title: Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis.
    Author: Ghossein C, Varga J, Fenves AZ.
    Journal: Curr Rheumatol Rep; 2016 Jan; 18(1):5. PubMed ID: 26711696.
    Abstract:
    Scleroderma renal crisis (SRC) is an uncommon complication of systemic sclerosis. Despite the advent of angiotensin-converting inhibitor therapy, SRC remains a life-threatening complication. Recent studies have contributed to a better understanding of SRC, but much remains unknown regarding its pathophysiology, risk factors, and optimal management. Genetic studies provide evidence that immune dysregulation might be a contributing factor, providing hope that further research in this direction might illuminate pathogenesis and provide novel predictors for this complication.
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