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  • Title: Highly oxygenated chromones from mangrove-derived endophytic fungus Rhytidhysteron rufulum.
    Author: Chokpaiboon S, Choodej S, Boonyuen N, Teerawatananond T, Pudhom K.
    Journal: Phytochemistry; 2016 Feb; 122():172-177. PubMed ID: 26712613.
    Abstract:
    Five highly oxygenated chromones, rhytidchromones A-E, were isolated from the culture broth of a mangrove-derived endophytic fungus, Rhytidhysteron rufulum, isolated from Thai Bruguiera gymnorrhiza. Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The structure of rhytidchromone A was further confirmed by single-crystal X-ray diffraction analysis. These compounds were evaluated for cytotoxicity against four cancer cell lines (MCF-7, Hep-G2, Kato-3 and CaSki). All compounds, except for rhytidchromone D, displayed cytotoxicity against Kato-3 cell lines with IC50 values ranging from 16.0 to 23.3μM, while rhytidchromones A and C were active against MCF-7 cells with IC50 values of 19.3 and 17.7μM, respectively.
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