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  • Title: Antibody- and Label-Free Phosphoprotein Sensor Device Based on an Organic Transistor.
    Author: Minamiki T, Minami T, Koutnik P, Anzenbacher P, Tokito S.
    Journal: Anal Chem; 2016 Jan 19; 88(2):1092-5. PubMed ID: 26713563.
    Abstract:
    An antibody- and label-free detection of a phosphoprotein (α-casein) has been achieved using an organic field-effect transistor (OFET)-based sensor. The fabricated OFET device possesses an extended-gate electrode functionalized with an artificial phosphoprotein receptor (Zn(II)-dipicolylamine complex, Zn(II)-DPA). It is shown that the OFET responds to the molecular recognition processes involving the Zn(II)-DPA at the extended-gate electrode. The binding of α-casein to the receptor in a HEPES solution results in an analyte-specific changes of the drain current of the OFET. The successful demonstration of the antibody- and label-free detection using the OFET could pave the way to the development of low-cost, disposable, and portable electronic sensor devices.
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