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  • Title: Clinical experience about an unexpected adverse event during nalmefene treatment in two patients with alcohol use disorder.
    Author: Milano G, Zavan V, Natta WM, Martelli A, Mattioli F.
    Journal: J Clin Pharm Ther; 2016 Feb; 41(1):97-100. PubMed ID: 26714742.
    Abstract:
    WHAT IS KNOWN AND OBJECTIVE: Nalmefene, a new opioid system regulator, has recently been approved for the treatment of alcohol dependence, primarily for reducing heavy drinking days. CASES DESCRIPTION: Two patients with a diagnosis of alcohol use disorder were treated with nalmefene. Both patients developed fatigue and deep sleepiness after 2 days of treatment. Only after 1 day of drug discontinuation, symptoms normalized. WHAT IS NEW AND CONCLUSION: We have analysed symptoms' development before and after treatment discontinuation and the possible association with nalmefene therapy. This case should pinpoint our attention on this adverse event for a careful choice of anticraving therapy in patients with severe alcohol use disorder.
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