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  • Title: [Pharmacologic effects of peripheral vasodilators in patients with secondary pulmonary hypertension].
    Author: Kukes VG, Tsoĭ AN, Abrosimov AG, Nasyrov ShN, Belov AM.
    Journal: Klin Med (Mosk); 1989 May; 67(5):52-6. PubMed ID: 2671486.
    Abstract:
    A single dose of capoten (25 mg) and prazosin (I mg) was given to 82 patients with stable pulmonary hypertension and chronic non-specific pulmonary diseases and to 34 patients with the above condition and arterial hypertension. Systolic and diastolic pressure in the system of the pulmonary artery and total pulmonary and total peripheral resistance were decreased; capoten exhibited more pronounced hypotensive effect. Unidirectional changes were revealed in the course treatment. Combined use of capoten, prazosin and euphilline produced the additional hypotensive effect on pulmonary circulation. Capoten and prazosin had no direct broncholytic effect.
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