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  • Title: Correlation of standard diffusion-weighted imaging and diffusion kurtosis imaging with distant metastases of rectal carcinoma.
    Author: Yu J, Huang DY, Li Y, Dai X, Shi HB.
    Journal: J Magn Reson Imaging; 2016 Jul; 44(1):221-9. PubMed ID: 26715111.
    Abstract:
    PURPOSE: To investigate the correlation of standard diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with distant metastases of rectal carcinoma. MATERIALS AND METHODS: Fifty-eight patients with rectal carcinoma (27 with distant metastasis and 31 with no metastasis) were included in this study. The apparent diffusion coefficient (ADC) value from standard DWI (b values of 0 and 1000 sec/mm(2) ), Dapp , and Kapp from DKI (b values of 0, 700, 1400, and 2000 sec/mm(2) ) were acquired with a 3.0T magnetic resonance imaging (MRI) scanner. These quantitative parameters were calculated from the entire tumors. Receiver operating characteristic curve analyses were conducted to assess the utility for discrimination of tumor with distant metastasis and those without metastasis. Parameters were compared using the independent-samples t-test. RESULTS: The histogram metrics 10th percentile of Dapp (Dapp-10th ) and ADC values (ADC10th ) were significantly lower in the distant metastasis group than those without metastasis (972.5 ± 118.8 vs. 1121.3 ± 133.8 × 10(-6) mm(2) /s, P = 0.03; 809.2 ± 67.1 vs. 856.2 ± 72.1 × 10(-6) mm(2) /s, P = 0.03). Dapp-10th showed relatively higher area under the curve (AUC) (0.856 vs. 0.669, P = 0.024), and higher specificity (100% vs. 68%) than ADC10th did for differentiation of lesions with distant metastasis from those without metastasis. CONCLUSION: DKI was relatively better than standard DWI in discriminating rectal carcinoma with distant metastasis from those without metastasis. J. Magn. Reson. Imaging 2016;44:221-229.
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