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  • Title: Effect of pH on mutagenesis by thiols in Salmonella typhimurium TA102.
    Author: Stark AA, Arad A, Siskindovich S, Pagano DA, Zeiger E.
    Journal: Mutat Res; 1989 Sep; 224(1):89-94. PubMed ID: 2671715.
    Abstract:
    The mutagenicity of thiol (SH)-containing compounds was tested in Salmonella typhimurium TA102 in the liquid preincubation method. Cysteinyl-glycine (CG), cysteine ethyl ester (CEE), L- and D-penicillamine (PA), cysteine (Cys) and glutathione (GSH) were mutagenic to strain TA102 without metabolic activation. On a molar basis, CG was the most potent mutagen. The mutagenicity of the remaining compounds decreased in the order specified above. The mutagenic response of each thiol-containing compound was a function of the pKa of the thiol group and the pH of the preincubation mixture. This indicates that a thiolate anion, rather than a free thiol, is required for mutagenesis.
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