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  • Title: A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
    Author: Hyman BT, Van Hoesen GW, Beyreuther K, Masters CL.
    Journal: Neurosci Lett; 1989 Jul 03; 101(3):352-5. PubMed ID: 2671814.
    Abstract:
    Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.
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